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What tissue type most directly gives rise to the lesion this patient is experiencing? Click here to purchase. Please login to add comment. The original A-P location of where the neural crest cells separate from the neural tube determines their ultimate function and cell type. The notochord is an embryologic structure that is important for paracrine signaling and cell differentiation. Illustration B summarizes the derivatives of the neural crest cells; melanocytes are represented as 'pigment cells' in this depiction.
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